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Timing and Number of cSCCs in Transplant Recipients
JAMA Dermatology; ePub 2018 May 16; Puza, et al
In a recent study, solid organ transplant recipients (SOTRs) experienced an average of 2.6 cutaneous squamous cell carcinomas (cSCCs) over a mean follow-up of 7.2 years with an average of 1.9 years elapsing between diagnosis of the first and second cSCC. This retrospective study consisted of renal, hepatic, and cardiothoracic adult (aged >18 years) transplant patients at Duke Medical Center. Pretransplant cSCC was the only exclusion criterion. Researchers found:
- 3,652 SOTRs were identified; cSCCs developed in 143 patients (3.9%) at a mean (SD) follow-up time of 7.2 (4.0) years after transplantation.
- Of the 143 patients, the mean (SD) number of cSCCs experienced was 2.6 (4.2) over the mean follow-up time, with an interquartile range of 2 cSCCs.
- 20 patients (14.0%) experienced their second cSCC within 6 months of their initial posttransplant cSCC.
- The renal group experienced a mean (SD) of 3.0 (4.1) cSCCs compared with 2.4 (2.0) cSCCs in the hepatic group and 2.6 (3.0) cSCCs in the cardiothoracic group.
- 76 patients (52.8%) experienced ≥2 cSCCs, with the mean (SD) latency time between first cSCC and second cSCC of 1.9 (2.0) years.
Puza CJ, Cardones AR, Mosca PJ. Timing and number of cutaneous squamous cell carcinomas in transplant recipients. [Published online ahead of print May 16, 2018]. JAMA Dermatology. doi:10.1001/jamadermatol.2018.0856.