Solid organ transplant recipients (SOTRs) have a higher prevalence of residual cutaneous squamous cell carcinoma (cSCC) after shave biopsy when compared with non-immunosuppressed controls, a recent study found, and should be prioritized for margin-controlled surgery. A retrospective case-controlled review was performed from a single center. Data were collected for 117 SOTRs and 117 age-matched non-immunosuppressed controls diagnosed with shave biopsy-proven cSCC who underwent subsequent wide local excision from January 2004 to December 2016. Multivariable conditional logistic regression was used to determine variables associated with residual tumor in the combined population. Univariate logistic regression was used to investigate if transplant-related variables were associated with residual tumor in the SOTR group. Researchers found:

• Of the 117 SOTRs, 57 (48.7%) had residual tumor within the excisional specimen.
• Of the 117 controls, 31 (26.5%) had residual tumor within the excisional specimen.
• SOTRs have 2.59 times greater odds of having residual cSCC after shave biopsy.