Psoriasis has been associated with an increased risk of numerous medical and psychiatric comorbidities, including suicidality, according to a recent investigation. Suicidality, which can be divided into the categories of suicidal ideation, suicide attempt, and completed suicide, is highly prevalent in the psoriasis population, and multiple studies have been published on the subject of psoriasis and suicidal ideation and behavior (SIB), including 2 recent meta‐analyses. This review aims to cohesively synthesize and summarize the available evidence, while making a clinically relevant distinction between the sub‐categories of suicidality, by examining not only the epidemiology of the association but also the plausible molecular mechanisms and the potential influence of biologic therapies. Additionally, investigators aim to critically examine and understand the potential contribution of depression in the psoriasis and suicidality relationship. This will allow for:

• better understanding of the complex and multi‐faceted relationship between psoriasis and suicidality,
• identifying those who may be most at risk for SIB,
• making evidence‐based clinical decisions regarding treatment and management,
• and more completely addressing the needs of psoriasis patients.