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Growing ADHD drug selection aids individualized therapy
With two new agents added to an already sizable list of long-acting stimulants in the last 4 months, ADHD therapy can be better individualized.
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In adolescents, treat substance use disorder before ADHD
Key clinical point: In adolescents with both attention-deficit/hyperactivity disorder and substance use disorder, control of substance use comes...
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New regimen for hepatitis C genotype 2 beats previous standard of care
A two-drug regimen without ribavirin was found superior to the current standard of care for genotype 2 (GT2) hepatitis C virus infection,...
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Proportion of HCV patients in U.S. with cirrhosis climbing
Key clinical point: Despite a national decline in the prevalence of hepatitis C virus infection, the prevalence of cirrhosis among HCV-infected...
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AASLD: HCV cure associated with reduction in all-cause mortality
Sustained virologic response in patients with hepatitis C virus infection is associated with large reductions in all-cause mortality and appears...
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Elevated liver cancer risk after HCV cure may justify surveillance
Sustained virologic response in patients with well controlled hepatic C virus infection does not protect select subgroups of this cohort from...
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Investigational hepatitis B therapy shows activity in proof-of-concept study
NVR 3-778, an experimental hepatitis B virus core inhibitor, showed substantial activity and was well tolerated in an initial phase Ib study.
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Sofosbuvir/R yields benefits in compassionate use HCV program
In real-world setting, sofosbuvir in combination with ribavirin (SOF/R) provided meaningful benefits for special populations with hepatitis C...
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Multitargeted drug combination promising when new HCV antivirals fail
Key clinical point: A five-drug antiviral combination appears to be effective for retreatment of patients with hepatitis C virus infection who...
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Regimen effective in genotype 3 HCV despite advanced cirrhosis
Sustained virologic response in patients with genotype 3 hepatitis C virus (HCV) infection and advanced fibrosis or cirrhosis was achieved in 88%...
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Cellular therapy benefit limited to young alcoholic hepatitis patients
The only patients with alcoholic hepatitis to derive a survival benefit from extracorporeal hepatocellular therapy with C3A hepatoma cells were...
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High SVR achieved in decompensated HCV patients with 12-week therapy
The findings are encouraging because current treatment options for patients with HCV who have decompensated liver disease are limited, Dr....
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New direct-acting antivirals for HCV perform well in real world
Discontinuation rates for the new direct-acting antivirals are “not a major issue” in real world clinical practice.