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Approach can reduce drug-induced TLS
Photo courtesy of EHA MILAN—The BCL-2 inhibitor ABT-199 may be a feasible treatment option for patients with chronic lymphocyctic leukemia/small...
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Cream provides relief for leg ulcers in SCD
The cream significantly decreased the size of leg ulcers overall, healed ulcers in 6 of the 18 patients studied, and reduced pain levels,...
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Leukemic breast tumors may cause resistance in AML, ALL
Isabel Cunningham, MD, of Columbia University in New York, has found evidence to suggest that treatment resistance in leukemia patients may...
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Reovirus shows synergy with agents used to treat MM
Six of the 7 MM cell lines tested were at least moderately sensitive to reovirus, and introducing the virus in combination with the proteasome...
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Group describes mechanism of resistance in CLL
The study suggests the TNF-family member BAFF contributes to CLL cells’ resistance to direct and rituximab-induced natural killer (NK) cell...
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Dual kinase inhibitor targets heterogeneity in AML
The inhibitor, SEL24-B489, targets both PIM and FLT3 mutants.
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Heparanase regulates response to chemo in MM, team says
Researchers first found that expression of heparanase, an endoglycosidase that cleaves heparan sulfate, is highly elevated in MM patients after...
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Molecule can increase Hb in anemic cancer patients
The molecule, lexaptepid pegol (NOX-H94), is a pegylated L-stereoisomer RNA aptamer that binds and neutralizes hepcidin. In this phase 2 study, 5...
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Combo may overcome bortezomib resistance in MCL
Experiments in MCL cell lines and mouse models of the disease showed that lenalidomide alone is active in bortezomib-resistant cells and tumors....
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Enrollment stalled for CAR T-cell study
Memorial Sloan-Kettering Cancer Center has temporarily suspended enrollment in a study of chimeric antigen receptor (CAR) T-cell therapy, due to 2...
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Analysis details effects of HLA mismatch
The study showed that a single allele- or antigen-level HLA mismatch (7/8) increased the risk for acute and chronic graft-vs-host disease (GVHD)...
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T cells protect from GVHD, preserve GVT effect
Donor-derived CD4+ invariant natural killer T cells (iNKT cells) helped protect mice from developing GVHD and lymphoma, thereby improving their...
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Order of Cy, TBI doesn’t impact HSCT outcome
In a large, retrospective study, the rates of relapse, survival, chronic graft-vs-host disease (GVHD), and other complications were similar...
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RIT can improve transplant outcomes in NHL, CLL
Ryan Cassaday, MD, of the University of Washington in Seattle, noted that RIT-augmented NMAT can produce long-term remissions in patients with...
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Study links graft source to length of hospital stay
The study also suggests the length of stay (LOS) is similar whether patients receive double or single CB grafts. So it seems strategies are...