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Drug that fell short in prostate cancer could treat MM
PHILADELPHIA—A drug that has fallen short of expectations in clinical trials of prostate cancer may be effective for treating multiple myeloma (MM...
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‘Watch and wait’ may be inadvisable for CLL
PHILADELPHIA—Withholding treatment from chronic lymphocytic leukemia (CLL) patients because they are of advanced age and have comorbidities may...
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Haplo-BMT feasible in high-risk malignancies
Photo by Chad McNeeley SAN DIEGO—Haploidentical bone marrow transplant (haplo-BMT) is a feasible option for patients with high-risk hematologic...
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Older age doesn’t decrease HRQOL among PBSC donors
Photo courtesy of Canterbury District Health Board SAN DIEGO—New research indicates that older stem cell donors have somewhat poorer overall...
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Ibrutinib demonstrates efficacy in CLL after allo-HSCT
Photo courtesy of CDC SAN DIEGO—Ibrutinib can produce favorable results in heavily pretreated patients with chronic lymphocytic leukemia (CLL)...
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Predicting outcomes of allo-HSCT in ALL
Photo by Chad McNeeley SAN DIEGO—A retrospective study has revealed a few factors that may predict outcomes of allogeneic hematopoietic stem cell...
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Product ‘solves engraftment problem’ with UCBT
Photo courtesy of NHS SAN DIEGO—A product that promotes CD34 expansion has solved the problem of poor engraftment associated with umbilical cord...
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Day 90 CR not a good endpoint for auto-HSCT, doc says
Photo by Rhoda Baer SAN DIGEO—A phase 3 study comparing conditioning regimens in multiple myeloma patients undergoing autologous transplant...
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Ro-CHOP: Toxicity increases with efficacy
Photo by Larry Young SAN FRANCISCO—Adding romidepsin to CHOP can enhance the regimen’s efficacy against peripheral T-cell lymphoma (PTCL), but...
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Mogamulizumab in PTCL: Europe vs Japan
Photo by Larry Young SAN FRANCISCO—Two phase 2 studies testing mogamulizumab in peripheral T-cell lymphomas (PTCLs) suggest that higher response...
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MicroRNA may be therapeutic target for ALK- ALCL
Photo by Larry Young SAN FRANCISCO—MicroRNA-155 (miR-155) can act as an oncogenic driver in ALK− anaplastic large-cell lymphoma (ALCL) and may...
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Combo shows early promise for T-cell lymphomas
Photo by Larry Young SAN FRANCISCO—Preclinical and early phase 1 results suggest the aurora A kinase inhibitor alisertib and the histone...
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A better HDAC inhibitor for PTCL?
Photo by Larry Young SAN FRANCISCO—The histone deacetylase (HDAC) inhibitor chidamide is effective and well-tolerated in patients with relapsed...
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Outcomes still dismal in PTCL, project shows
Photo by Larry Young SAN FRANCISCO—Outcomes remain dismal for the majority of patients with peripheral T-cell lymphoma (PTCL), according to a...
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Distribution of PTCL subtypes varies by race/ethnicity
Photo by Larry Young SAN FRANCISCO—The distribution of peripheral T-cell lymphoma (PTCL) subtypes in the US varies greatly according to race and...