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Combo improves response rates in treatment-naïve SAA
Adding eltrombopag to immunosuppressive therapy (IST) can produce high rates of response in treatment-naïve severe aplastic anemia (SAA),...
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Cutting amino acids from diet could fight lymphoma
Cutting certain amino acids from the diet slows tumor growth and prolongs survival in mouse models of malignancy, according to research published...
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Hemoglobin nanoparticles could serve as blood substitute
A new type of hemoglobin-based oxygen carrier has shown early promise as a potential blood substitute, according to researchers. The team created...
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Method could prevent GVHD while preserving GVL effect
Researchers believe they have found a way to prevent graft-versus-host disease (GVHD) after hematopoietic stem cell transplant (HSCT) while...
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CAR T-cell therapy receives breakthrough designation
The US Food and Drug Administration (FDA) has granted another breakthrough therapy designation to CTL019 (tisagenlecleucel-T), an investigational...
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Study correlates genetic mutations with AML subgroups
A large study of adults with acute myeloid leukemia (AML) correlates cancer-related genetic mutations with subtypes of AML defined by the presence...
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Analysis reveals common sources of bias in scientific research
A recent study suggested that bias in research varies across scientific disciplines, but there are some common factors the different fields share...
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Nanoparticles allow for creation of CAR T cells in vivo
Researchers say they have developed biodegradable nanoparticles that can be used to genetically reprogram T cells while they are still in the body...
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Health Canada expands approval of daratumumab in MM
The drug is now approved for use in combination with lenalidomide and dexamethasone or bortezomib and dexamethasone to treat MM patients who have...
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Inhibitor exhibits activity against hematologic malignancies
A dual kinase inhibitor is active against a range of hematologic malignancies, according to preclinical research. Investigators found that ASN002...
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Early prophylaxis may preserve joint health in hemophilia patients
New research suggests that starting prophylactic factor VIII (FVIII) therapy early in life can preserve joint health in patients with hemophilia A...
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Imbalance drives development of B-ALL, team says
Researchers say they have discovered an imbalance that drives the development of B-cell acute lymphoblastic leukemia (B-ALL). The group’s study...
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TKI shows promise in preclinical study of AML
WASHINGTON, DC—Preclinical data suggest a novel tyrosine kinase inhibitor (TKI) may be an effective treatment for patients with NTRK-rearranged...
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Leukemia, NHL more common in African-born blacks than US-born blacks
The cancer profile of black US immigrants born in sub-Saharan Africa (ABs) differs from that of US-born black individuals (USBs) and varies by...
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Therapy increases factor IX activity in hemophilia B
SCOTTSDALE, ARIZONA—The investigational therapy SPK-9001 delivers “consistent and sustained” increases in factor IX (FIX) activity in patients...