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Intrabone gene therapy shows promise in beta-thalassemia
ATLANTA – Intrabone gene therapy could offer long-term hope for patients with beta-thalassemia who cannot be treated by allogeneic HSCT.
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Gene therapy normalized or near-normalized factor VIII in hemophilia A
ATLANTA – Gene therapy is “holy grail” for managing hemophilia – a single-gene disorder with a clear relationship between clotting factor level...
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AGA Clinical Practice Update: Treatment of fecal incontinence and defecatory disorders
Conservative treatment is recommended in all cases before surgery is considered.
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VIDEO: Project ECHO would cost-effectively expand HCV treatment
The project is a teletraining model that would increase the efficiency of treatment.
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Biologics during pregnancy did not affect infant vaccine response
There was no link between median infliximab concentration in uterine cord blood and antibody titers among infants.
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VIDEO: Study supports close follow-up of patients with high-risk adenomas plus serrated polyps
The combination seems to further increase the risk of adenoma.
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Adjusting fecal immunochemical test thresholds improved their performance
Rather than simply using thresholds recommended by the manufacturer, screening programs should choose thresholds based on intended levels of...
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Frailty, not age, predicted complications after ambulatory surgery
Frailty was associated with a significant increase in 30-day complications after ambulatory hernia repair.
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ACOG updates guidance on pelvic organ prolapse
The interim update incorporates new systematic review evidence on the use of biologic and synthetic mesh grafts for anterior POP repair.
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ACOG: VBAC is safe for many women
Rates of vaginal birth after cesarean delivery were more than 28% in 1996 but fell to 8.5% by 2006.
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Low tryptophan levels linked to IBD
There was no link between dietary tryptophan consumption and disease activity.
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Study highlights disparities in U.S. lupus mortality
Sex, race, and geographic region were independent risk factors for SLE mortality.
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VIDEO: High-volume endoscopists, centers produced better ERCP outcomes
Systematic review had varying definitions of low-volume and high-volume centers.
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IDSA updates infectious diarrhea guidelines
Molecular-based diagnostic tests are very sensitive, but may require expert analysis.
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Biofeedback significantly improves abdominal distension in small study
Patients met Rome III criteria for functional intestinal disorders.