Clinical Edge

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Defining Construct Validity & Cutoffs for the FLARE-RA Questionnaire

Proposed FLARE-RA cutoffs have acceptable discriminative capacity across the tested anchor items and are expected to aid in early recognition and timely management of rheumatoid arthritis (RA) flares, a new study found. The cross-sectional study included adult patients with prevalent RA. Flare occurrence over the past 3 months was evaluated with the FLARE-RA questionnaire scoring from 0 (no flare) to 10 (maximum flare). Researchers found:

  • 474 patients with RA duration ≥2 years were included in the main analysis.
  • The discrimination for the FLARE-RA cutoffs was acceptable to excellent.
  • Proposed FLARE-RA cutoffs for clinical detection and change of anti-rheumatic treatment are 2 and 5, respectively, for patients with RA duration 2-5 years, and 2 and 3.5, respectively, for patients with RA duration >5 years.

Citation:

Myasoedova E, et al. Definition and construct validation of clinically relevant cutoffs on the FLARE-RA questionnaire. [Published online ahead of print September 11, 2019]. Semin Arthritis Rheum. doi: 10.1016/j.semarthrit.2019.09.004.