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Coexistent Hyperuricemia and Gout in RA

Publish date:: June 3, 2019

Strong associations of hyperuricemia with cardiovascular disease (CVD) mortality exists among patients with rheumatoid arthritis (RA), a new study found, a risk that appears to be driven by excess comorbidity. Participants from a longitudinal RA study were categorized by the presence of gout and serum urate (sUA) status. Groups were compared by baseline patient characteristics, RA disease activity, treatments, and comorbidities. Researchers found:

Of 1,999 participants with RA, 341 (17%) had sUA concentrations >6.8 md/dL and 121 (6.1%) were diagnosed with gout.
There were no significant associations of enrollment sUA or gout with RA disease activity or treatment.
After age and sex adjustment, moderate hyperuricemia was associated with an increased risk of CVD-related mortality.

Citation:

Chiou A, et al. Coexistent hyperuricemia and gout in rheumatoid arthritis: Associations with comorbidities, disease activity and mortality. [Published online ahead of print May 10, 2019]. Arthritis Care Res (Hoboken). doi: 10.1002/acr.23926.

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