Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Older Men with Hip Fractures Suffer BMD Decline

Osteoporos Int; ePub 2017 Oct 24; Rathbun, et al

Hip fracture in older men is associated with accelerated bone mineral density (BMD) declines at the non-fractured hip that are greater than those expected during aging, a recent study found. 2 cohorts were used: Baltimore Hip Studies 7th cohort (BHS-7) and Baltimore Men’s Osteoporosis Study (MOST). BHS-7 recruited older adults (n=339) hospitalized for hip fracture; assessments occurred within 22 days of admission and at 2- , 6- , and 12-month follow-ups. MOST enrolled age-eligible men (n=694) from population-based listings; data were collected at a baseline visit and a second visit that occurred between 10 and 31 months later. The combined sample (n= 452) consisted of Caucasian men from BHS-7 (n=89) and MOST (n=363) with ≥2 dual-energy X-ray absorptiometry scans and overlapping ranges of age, height, and weight. Researchers found:

  • Adjusted changes in total hip and femoral neck BMD were −4.16% and −4.90% in BHS-7 participants.
  • Adjusted changes were −1.57% and −0.99% in MOST participants.
  • Statistically significant between-group differences in change were −2.59% and −3.91%, respectively.

Citation:

Rathbun AM, Magaziner J, Shardell MD, et al. Older men who sustain a hip fracture experience greater declines in bone mineral density at the contralateral hip than non-fractured comparators. [Published online ahead of print October 24, 2017]. Osteoporos Int. doi:10.1007/s00198-017-4280-0.