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Calcium Plus Vitamin D in Fracture Reduction

Meta-analysis of hip and total fractures

Publish date:: November 2, 2015

The use of calcium plus vitamin D supplements is an effective intervention for fracture risk reduction in both community-dwelling and institutionalized middle-aged to older adults, according to meta-analysis of 8 randomized clinical trials totaling 30,970 participants, including 195 with hip fractures and 2,231 total fractures. Researchers found:

• Calcium plus vitamin D supplementation produced a statistically significant 15% reduced risk of total fractures and a 30% reduced risk of hip fractures.

• Numerous sensitivity and subgroup analyses produced similar summary associations.

Citation: Weaver CM, Alexander DD, Boushey CJ, et al. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. [Published online ahead of print October 28, 2015]. Osteoporosis Int. doi: 10.1007/s00198-015-3386-5.

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