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Atrophic Phenotype of OA and Disease Progression
Osteoarthritis Cartilage; ePub 2017 Jun 9; Crema, et al
The atrophic phenotype of knee osteoarthritis (OA) was associated with a decreased likelihood of progression of joint space narrowing (JSN) and cartilage loss compared to the non-atrophic knee OA phenotype, a recent study found. Participants of the Multicenter Osteoarthritis (MOST) Study with available radiographic and MRI assessments at baseline and 30 months were included (476 knees from 432 participants). Researchers found:
- There were 50 (10.5%) knees with atrophic OA using the radiographic definition, and 16 (3.4%) knees with atrophic OA using MRI definition.
- Non-atrophic OA knees more commonly exhibited fast progression of JSN and cartilage damage.
- Logistic regression showed that the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss.
Crema MD, Felson DT, Guermazi A, et al. Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study. [Published online ahead of print June 9, 2017]. Osteoarthritis Cartilage. doi:10.1016/j.joca.2017.05.019.