In a recent study, researchers confirmed known calcium pyrophosphate deposition disease (CPDD) associations with medical comorbidities; provided support for positive associations with rheumatoid arthritis (RA), hypomagnesemia, and osteoporosis; and suggested potential novel negative associations with commonly used medications. They identified 25,157 VA patients with CPDD yielding a point prevalence of 5.2 per 1,000; the average age was 68.1 ±12.3 years and 95% were male. They found:

• The strongest positive associations with CPDD were hyperparathyroidism, gout, osteoarthritis, RA, and hemochromatosis.
• Positive associations were also seen with higher odds for osteoporosis, hypomagnesemia, chronic kidney disease, and calcium supplementation.
• Negative associations were seen with proton pump inhibitors and loop diuretics.