Resilience in people with schizophrenia is the ability to identify and to apply their talents and strengths to manage the challenges of psychiatric symptoms and stigma. Internalized stigma occurs when people accept and apply negative and stigmatizing societal attitudes towards themselves. While the literature on stigma and mental illness is extensive, there is a more limited literature on how best to combat stigma so that people who experience both societal (external) and self (internal) stigma can have a better quality of life. An important contribution of this report is insight into potentially modifiable engagement targets for interventional approaches that have potential to positively impact health outcomes and quality of life for people with schizophrenia. Future research might, for example, assess whether patient-facing approaches such as self-management training engages and improves self-esteem and resilience. The report also underscores the complex nature of recovery beyond symptoms and functional status that are standard outcomes in schizophrenia clinical trials. —Martha Sajatovic, MD, Professor of Psychiatry and of Neurology; Willard Brown Chair in Neurological Outcomes Research; Director, Neurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center; Case Western Reserve University School of Medicine.