Key clinical point: Increased serum prolactin concentration is significantly associated with aggression in female patients with schizophrenia, irrespective of the antipsychotic medication.

Major finding: Serum prolactin levels were significantly increased in aggressive patients vs. non-aggressive patients (P less than .0001). Aggressive patients treated with risperidone, haloperidol, paliperidone, and amisulpride (P = .036) and a group not treated with these antipsychotics (P less than .001) had significantly higher prolactin levels vs. non-aggressive patients. Higher antipsychotic dose correlated with increased prolactin concentration (P = .004).

Study details: The findings are based on a prospective-retrospective study of 120 female patients diagnosed with schizophrenia who had been admitted for inpatient treatment.

Disclosures: No study sponsor was identified. The authors declared no conflicts of interest.