There was no statistically significant elevated risk of primary ovarian insufficiency (POI) after human papillomavirus (HPV); tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis, adsorbed (Tdap); inactivated influenza (II); or meningococcal conjugate (MenACWY) vaccination, according to a recent population-based, retrospective cohort study. These findings, therefore, should lessen concern about POI risk after adolescent vaccination. Researchers searched Kaiser Permanente Northwest electronic health records for outpatient diagnoses suggestive of POI in female patients aged 11 to 34 years between 2006 and 2014. They reviewed and adjudicated the medical record to confirm diagnoses and estimate symptom onset dates. They found:

• From a cohort of 199,078 female patients, 120 with diagnoses suggestive of POI were identified.
• After adjudication and exclusion of 26 POI cases with known causes, 46 idiopathic POI cases were confirmed.
• POI incidence was low in 11- to 14-year-olds (0.87 per 1,000,000 person-months) and increased with age.
• The adjusted hazard ratio was 0.30 after HPV, 0.88 after Tdap, 1.42 after II, and 0.94 after MenACWY vaccination.