Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Cerebral Venous Thrombosis & Steroids in Meningitis
Open Forum Infect Dis; 2017 Oct; Gallegos, et al
Giving adults with bacterial meningitis adjunctive steroids may increase the risk of delayed cerebral venous thrombosis, suggests a recent retrospective multicenter analysis at 10 Houston hospitals.
- Among 120 patients with culture-verified community-acquired bacterial meningitis, 82 (68%) received adjunctive IV steroids for an average of 3.8 days.
- Delayed cerebral venous thrombosis was observed in 9 (7.5%) patients with bacterial meningitis, only 1 of whom had not received steroids.
- 5 of the meningitis patients who had DCT had been infected with Streptococcus pneumoniae, 1 by Listeria monocytogenes, and 2 with Staphylococcus aureus.
Gallegos C, Salazar L, Tobolowsky F, et al. Use of adjunctive steroids and incidence of delayed cerebral venous thrombosis in adults with bacterial meningitis. Open Forum Infect Dis. 2017;4 (Suppl 1): S7-S8. doi:10.1093/ofid/ofx162.019.
This Week's Must Reads
Must Reads in Meningitis
Cerebral Venous Thrombosis & Steroids in Meningitis, Open Forum Infect Dis; 2017 Oct; Gallegos, et al
Early Onset GBS Meningitis Drops, Late Onset Jumps, Clin Infect Dis; 2017 Oct 16; Romain, et al
Better Diagnostic Tests for Histoplasma Meningitis, Clin Infect Dis; 2017 Aug 20; Block, et al
Understanding Meningococcal Disease, Asian Pac J Trop Med; 2017 Nov; Batista, et al
Cryptococcal Meningitis Takes Toll on HIV Patients, Clin Infect Dis; 2017 Oct 4; Pasquier, et al