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Filaggrin Loss-of-Function Variants in Children with Atopic Dermatitis

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In a US cohort of children with mild-to-moderate atopic dermatitis (AD), the filaggrin gene (FLG) loss-of-function (LoF) variants differed significantly by race and their association with the persistence of AD. The prospective study assessed the genetic subcohort of the Pediatric Eczema Elective Registry (PEER). The primary outcomes were the associations of FLG LoF variation with white and African American ancestry and with the risk of persistence of AD. Researchers found:

  • 741 children were included in the analysis; of these, 394 were white, 326 were African American, and 21 had other ancestries.
  • 23 FLG LoF variants were found in children with AD.
  • The prevalence of FLG LoF variants was 177 participants in the full cohort, 124 white participants, and 50 African American participants.
  • Children with an FLG LoF were more likely to have persistent AD.

Citation:

Margolis, et al. Association of filaggrin loss-of-function variants with race in children with atopic dermatitis. [Published online ahead of print July 31, 2019]. JAMA Dermatol. doi: 10.1001/jamadermatol.2019.

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