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Progestogen for Prevention of Recurrent Miscarriage
Cochrane Database; ePub 2018 Oct 8; Haas, et al
Supplementation with progestogen therapy in women with unexplained recurrent miscarriages probably reduces the rate of miscarriage in subsequent pregnancies. This according to a review Cochrane review that assessed the efficacy of safety of progestogens as a preventative therapy against recurrent miscarriage. 13 trials involving 2,556 women met inclusion criteria. Among the findings:
- Giving progestogen medication to women with recurrent miscarriages early in their pregnancy may help lower the rates of miscarriage in that pregnancy from 26.3% to 19.4%.
- Progestogen treatment may be most beneficial for women who had at least 3 miscarriages before they started the study.
- There was probably a slight benefit for women receiving progestogen seen in the outcome of live birth rate.
- A possible reduction in stillbirth was observed, but this outcome was driven mainly by 1 trial.
Citation:
Haas DM, Hathaway TJ, Ramsey PS. Progestogen for preventing miscarriage in women with recurrent miscarriage of unclear etiology. Cochrane Database of Systematic Reviews 2018, Issue 10. Art. No.: CD003511. doi:10.1002/14651858.CD003511.pub4.