The postpartum use of nonsteroidal anti-inflammatory drugs is not associated with increased rates of persistent postpartum hypertension in women with preeclampsia and severe features before delivery. This according to a retrospective cohort study of 399 women with severe preeclampsia from January 2013 to December 2015; 324 (81%) remained hypertensive for >24 hours after delivery and were included. 243 (75%) received NSAIDs (either ibuprofen or ketorolac) and 81 (25%) did not. The primary outcome was the rate of persistent postpartum hypertension. Researchers found:

• The likelihood of reaching a blood pressure of 150 mmHg systolic or 100 mmHg diastolic (or both), on 2 occasions, as least 4 hours apart, was similar between those who received NSAIDs vs those who did not (70% vs 73%, adjusted OR 1.1).
• Similarly, puerperal occurrence of pulmonary edema, renal dysfunction, eclampsia, or intensive care unit admission was similar between the groups.
• There was no difference in the rate of narcotic use.