Key clinical point: Physical activity increased peripheral levels of brain-derived neurotrophic factor (BDNF) in patients with multiple sclerosis (MS).
Major finding: Serum BDNF concentrations were significantly higher after exercise intervention compared with the preintervention levels (standardized mean difference 0.3309; P = .0275).
Study details: This was a meta-analysis of 13 exercise intervention clinical trials involving 271 patients with MS.
Disclosures: The authors did not receive any funding for this work. The authors declared no conflicts of interest.
Source: Shobeiri P et al. Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials. PLoS One. 2022;17(3):e0264557 (Mar 3). Doi: 10.1371/journal.pone.0264557