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Parkinsonism, PD Increase in Men Noted, 1976-2005

JAMA Neurol; ePub 2016 Jun 20; Savica, et al

Publish date:: July 12, 2016

The incidence of parkinsonism and Parkinson disease (PD) may have increased between 1976 and 2005, particularly in men aged ≥70 years, a recent study suggested. These trends may be associated with the drastic changes in smoking behavior that took place in the second half of the 20^th century or with other lifestyle or environmental changes. Researchers evaluated 906 patients with parkinsonism (501 were men, median age at onset, 74 years) and 464 patients with PD (275 were men, median age at onset, 73 years). They found:

• The overall incidence rates increased significantly over 30 years in men for both parkinsonism and PD.

• These trends were driven primarily by the older age groups.

• In particular, for men ≥70 years, incidence rates increased for both parkinsonism and PD.

• The secular trends were not significant for women overall or in age strata.

Citation: Savica R, Grossardt BR, Bower JH, Ahlskog JE, Rocca WA. Time trends in the incidence of Parkinson disease. [Published online ahead of print June 20, 2016]. JAMA Neurol. doi:10.1001/jamaneurol.2016.0947.

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