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Secondary bile acid deficiency may be culprit in UC inflammation

Publish date:: February 27, 2020

Key clinical point: Dysbiosis induces secondary bile acid deficiencies that promote intestinal inflammation.

Major finding: Average deoxycholic acid counts were 60,957 in familial adenomatous polyposis versus 1,593 in ulcerative colitis.

Study details: Stool profiles of 17 patients with ulcerative colitis and 7 with familial adenomatous polyposis, plus mouse studies of secondary bile acid supplementation.

Disclosures: Dr. Sinha received funding from the Crohn’s & Colitis Foundation, Stanford Clinical and Translational Science Award, and Kenneth Rainin Foundation Synergy Award. Coauthors received funding from the National Institutes of Health, the Ann and Bill Swindells Charitable Trust, Leslie and Douglas Ballinger, and the Kenneth Rainin Foundation.

Citation:

Sinha SR et al. Cell Host Microbe. 2020 Feb 25. doi: 10.1016/j.chom.2020.01.021.

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