Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Clock gene disruption might underlie IBD
Key clinical point: Disrupted clock gene expression may contribute to the pathogenesis of inflammatory bowel disease.
Major finding: Multiple clock genes showed reduced mRNA expression in inflamed and uninflamed intestinal mucosa and peripheral white blood cells from patients, compared with corresponding samples from controls. Differences often reached statistical significance.
Study details: Prospective study of 14 patients with newly diagnosed, untreated inflammatory bowel disease and 18 healthy controls.
Disclosures: The researchers did not report external funding sources. They reported having no conflicts of interest.
Weintraub Y et al. Clin Gastroenterol Hepatol. 2019 April 10. doi: 10.1016/j.cgh.2019.04.013.