Leukemia, Myelodysplasia, Transplantation
News
FDA grants drug orphan designation for AML
Actimab-A consists of the CD33 antibody lintuzumab linked to the actinium-225 payload.
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Targeting enzyme can eliminate CSCs in AML
Inhibiting the enzyme 5-lipoxygenase (5-LO) can eradicate cancer stem cell-like cells (CSCs) in acute myeloid leukemia (AML), according to a...
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NICE expands use of ESAs in cancer patients
chemotherapy Credit: Rhoda Baer The UK’s National Institute for Health and Care Excellence (NICE) has updated its guidance to expand the use of...
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Mutations indicate predisposition to blood cancers
Credit: Graham Colm Two teams of researchers have identified somatic mutations that increase the likelihood a person will develop a hematologic...
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Leukemia survival rates vary widely across the globe
Credit: Bill Branson A large, international study has revealed sizable differences in cancer survival rates between countries. In particular,...
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CAR T-cell therapy gets breakthrough designation
Credit: Charles Haymond The US Food and Drug Administration (FDA) has granted breakthrough therapy designation for JCAR015, a chimeric antigen...
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Ponatinib approved in Australia
The Therapeutic Goods Administration (TGA) has approved marketing of ponatinib (Iclusig) in Australia. The drug is now approved to treat adults...
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A new treatment option for elderly AML patients?
Credit: NIH In a phase 2 study, the anticancer quinolone derivative vosaroxin produced responses in poor-risk, elderly patients with previously...
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Exposure to hookah smoke may raise risk of blood cancers
Credit: Steven Damron A new study indicates that individuals exposed to hookah smoke have an increase in the uptake of benzene, a substance...
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Compounds can target Ras pathway
Credit: NIH A newly identified class of compounds recognize a key target in the Ras signaling pathway and could therefore prove useful in...
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FDA grants drug orphan designation for AML
Credit: Lance Liotta The US Food and Drug Administration (FDA) has granted orphan drug designation for the Axl inhibitor BGB324 to treat acute...