Despite high relapse rates, peripheral T-cell lymphoma (PTCL), except adult T-cell lymphoma/leukemia (ATLL), carries a low risk of CNS involvement, according to a study of 231 patients with any subtype of PTCL. Researchers found:

• Histologies included:

◊ Peripheral T-cell lymphoma–not otherwise specified (31.6%).

◊ Angioimmunoblastic (16.9%).

◊ Anaplastic large cell lymphoma (ALCL; 12.1%).

◊ ALCL, ALK + (6.1%).

◊ Extranodal NK/T-cell lymphoma (7.4%)

◊ ATLL (7.4%).

◊ Transformed mycosis fungoides (8.7%).

• 17 patients had CNS disease (7%); 15 had CNS involvement with PTCL and 2 had diffuse large B-cell lymphoma and glioblastoma.

• Median time to CNS involvement was 3.44 months.

• CNS prophylaxis was given to 24 patients.

• Rates of CNS involvement were not different in patients who received prophylaxis.

• Univariate analysis identified stage III–IV, bone marrow involvement, >1 extranodal site, and ATLL as risk factors for CNS disease.

• In multivariate analysis, >1 extranodal site and international prognostic index (IPI) ≥3 were predictive for CNS involvement.

• Median survival of patients with CNS involvement was 2.63 months.

Citation: Gurion R, Mehta N, Migliacci JC, et al. Central nervous system involvement in T-cell lymphoma: A single center experience. [Published online ahead of print April 4, 2016]. Acta Oncol. doi:10.3109/0284186X.2015.1118656.