Recovery of renal function after partial nephrectomy depends heavily on parenchymal mass preservation and ischemia characteristics, according to a study involving 405 individuals. Participants underwent partial nephrectomy at a single center between 2007 and 2015. Investigators looked at factors impacting renal functional status/recovery. Among the results:

• Median tumor size was 3.5 cm.
• R.E.N.A.L. score was 8.
• ~Two-thirds of patients had warm ischemia and ~one-third cold ischemia.
• The median ipsilateral glomerular filtration rate (GFR) preserved was 79%.
• Age, comorbidity index, hypertension, and proteinuria were all linked with preoperative GFR.
• Parenchymal mass preserved and ischemia type and duration were significantly linked with functional recovery.
• On multivariable analysis, none of the analyzed comorbidities were linked with functional recovery.

The authors noted that although comorbidities can impact long-term functional stability, they do not appear to influence short-term recovery.