Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Reducing Renal Cell Carcinoma Risk

Micronutrient linked to 39% risk reduction

Publish date:: February 26, 2015

A diet rich in the antioxidant lycopene is associated with a decreased risk of renal cell carcinoma (RCC), according to a dietary analysis of 96,196 postmenopausal women in the Women’s Health Initiative (WHI).

Investigators studied 7 micronutrients as reported on the WHI food intake questionnaire—α-carotene, β-carotene, β-cryptoxanthin, lutein plus zeaxanthin, lycopene, vitamin C, and vitamin E—and found an inverse association between RCC risk and dietary lycopene.

Women in the highest quartile of lycopene intake had a 39% lower risk compared to those in the lowest quartile. No other micronutrient studied was significantly associated with RCC risk.

Citation: Ho WJ, Simon MS, Yildiz VO, et al. Antioxidant micronutrients and the risk of renal cell carcinoma in the Women's Health Initiative cohort. Cancer. 2015;121(4):580-588. doi: 10.1002/cncr.29091.

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Mortality risks rise with age, infections, but not inhibitor status in persons with non-severe hemophilia A,

‘Impressive’ local control with MRI-guided brachytherapy in cervical cancer,

U.S. mothers underestimate role breastfeeding plays in curbing breast cancer,