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Predicting RCC Recurrence After Nephrectomy

What story do 16 genes tell?

Publish date:: May 19, 2015

A recurrence score developed from 11 genes associated with recurrence-free interval and 5 reference genes provides a more accurate and individualized risk assessment than current methods, according to a study of 1,568 patients with renal cell carcinoma (RCC) who had recently undergone nephrectomy. Researchers found that the recurrence score was:

• Significantly associated with recurrence-free interval for a 25-unit increase in score

• Significantly associated with risk of tumor recurrence after stratification by stage and adjustment for tumor size, grade, or Leibovich score

• Able to identify a clinically significant number of high-risk stage I and low-risk stage II to III patients

Citation: Rini B, Goddard A, Knezevic D, et al. A 16-gene assay to predict recurrence after surgery in localised renal cell carcinoma: development and validation studies [published online ahead of print May 12, 2015]. Lancet Oncology. doi:10.1016/S1470-2045(15)70167-1.

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