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Predicting Long-Term Survival After Allo-HCT

Biol Blood Marrow Transplant; ePub 2018 Jan 21; Patel, et al

Certain disease and transplant-related factors—along with patient socioeconomic status—can predict long-term survival after allogeneic hematopoietic cell transplantation (allo-HCT), researchers concluded after conducting a study involving 413 individuals. Participants underwent first-time allo-HCT between 2006 and 2014. Three-fourths received a myeloablative transplant; bone marrow was used in ~half. Investigators looked at predictors of surviving >100 days. Among the results:

  • 1-year all-cause mortality rate was 29%.
  • Relapse mortality and non-relapse mortality rates were 16% and 12%, respectively.
  • Patients who relapsed within the first 100 days had a >4-fold elevated risk of worse all-cause mortality.
  • Those with high-risk disease and non-cytomegalovirus infection had elevated all-cause mortality risk of 55% and 79%, respectively.
  • Patients who received bone marrow and umbilical cord blood had 48% and 60% lower risk of all-cause mortality, respectively.
  • Longer hospitalization increased the risk by 16%, whereas higher income lowered it by 11%.

Citation:

Patel S, Rybicki L, Corrigan D, et al. Prognostic factors for mortality among day 100 survivors after allogeneic hematopoietic cell transplantation. [Published online ahead of print January 21, 2018]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2018.01.016

Patel S, Rybicki L, Corrigan D, et al. Prognostic factors for mortality among day 100 survivors after allogeneic hematopoietic cell transplantation. [Published online ahead of print January 21, 2018]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2018.01.016