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Obesity and Endometrial Cancer Mortality Risk
Cancer Epidemiol Biomarkers Prev; ePub 2017 Jan 4; Busch, et al
Obesity may be linked with greater endometrial tumor expression of estrogen receptor (ER) and progesterone receptor (PR), according to a study involving 360 endometrial primary tumors.
Investigators measured ER and PR protein expression in tissue specimens from participants in the Nurses' Health Study. They explored the impact of different definitions of marker positivity, looking at different cut points in increments of 5% positive cells. Among the results:
- Obese individuals’ odds of having an ER-positive tumor at cut points of 0% to 20% were nearly 3-fold higher.
- Their odds of having a PR-positive tumor at cut points of 70% to 90% were more than twice as high.
- Adding dichotomous tumor ER or PR status to standard predictors did not improve model discrimination or calibration.
Busch E, Crous-Bou M, Prescott J, et al. Endometrial cancer risk factors, hormone receptors, and mortality prediction. [Published online ahead of print January 4, 2017]. Cancer Epidemiol Biomarkers Prev. doi:10.1158/1055-9965.EPI-16-0821.