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Multifactor Interaction and Ovarian Cancer Risk

Cancer Epidemiol Biomarkers Prev; ePub 2016 Mar 14; Usset, et al

Publish date:: March 22, 2016

Assessment of multifactor interaction is feasible in large genetic epidemiology studies, according to a study of 11,441 single nucleotide polymorphisms (SNPs) within 80 genes using data from 6,247 women with ovarian cancer and 10,379 controls. Researchers found:

• SNPs in the following candidate genes showed notable interaction:

◊ IGF1R (rs41497346, estrogen plus progesterone hormone therapy, histology = all).

◊ ESR1 (rs12661437, endometriosis, histology = all).

• The most notable obesity - gene - hormone risk factor interaction was within INSR (rs113759408, parity, histology = endometrioid).

Citation: Usset JL, Raghaven R, Tyrer JP, et al. Assessment of multifactor gene-environment interactions and ovarian cancer risk: candidate genes, obesity, and hormone-related risk factors. [Published online ahead of print March 14, 2016]. Cancer Epidemiol Biomarkers Prev. doi:10.1158/1055-9965.EPI-15-1039.

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