Large-scale genomic analyses of the 3 most common histologic types of lung cancer—adenocarcinoma, squamous-cell carcinoma, and small-cell carcinoma—were recently reviewed. The authors covered:

• Genomic alterations, including the genomic landscape; chromosomal changes and alterations in gene copy number; DNA single-nucleotide alterations and insertion and deletions; epigenetic alterations; transcriptome alterations; pathway alterations; and cell of origin.

• Clonal evolution and intratumor heterogeneity.

• Clinical implications, including identification of molecular targets for therapy; implications for clonal evolution in lung cancer; predictors of response to immunotherapy; and potential uses of circulating tumor biomarkers.

• Directions of future research.

Citation: Swanton C, Govindan R. Clinical implications of genomic discoveries in lung cancer. N Engl J Med. 2016;374(19):1864-1873. doi:10.1056/NEJMra1504688.