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Familial Risk in Cancers of Unknown Primary

What are the risks for first- and second-degree relatives?

Publish date:: January 5, 2016

Relatives of patients with cancers of unknown primary (CUP) are at increased risk of CUP and several other malignant neoplasms, including lung, pancreatic, and colon cancer, according to a study of 4,160 patients who received a diagnosis of CUP. Researchers found:

• First-degree relatives of patients with CUP were at an increased risk of CUP themselves (HR=1.35), as well as lung (HR=1.37), pancreatic (HR=1.28), myeloma (HR=1.28), and non-Hodgkin lymphoma (HR=1.16) cancers vs controls without CUP.

• With analysis restricted to relatives of cancer-free controls, additional risks for colon (HR=1.19), and bladder (HR=1.18) were seen.

• Second-degree relatives of patients with CUP were at slight increased risk of lung (HR=1.14), pancreatic (HR=1.17), breast (HR=1.09), melanoma (HR=1.09), and ovarian (HR=1.19) cancers.

Citation: Samadder NJ, Smith KR, Hanson H, et al. Familial risk in patients with carcinoma of unknown primary. [Published online ahead of print December 17, 2015]. JAMA Oncol. doi: 10.1001/jamaoncol.2015.4265.

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