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Coffee Intake in CRC
How does it influence recurrence and mortality?
Higher coffee intake may be associated with significantly reduced cancer recurrence and death in patients with stage III colon cancer, according to a study of 953 patients with stage III colon cancer, during and 6 months after adjuvant chemotherapy. Researchers found that compared to patients who abstained from coffee:
• Patients consuming 4 or more cups of total coffee daily experienced an adjusted hazard ratio (HR) of 0.58 for recurrence or mortality.
• Patients consuming 4 or more cups of caffeinated coffee experienced significant reduced risk of recurrence or mortality (HR, 0.48).
• Increasing caffeine intake also conferred a significant reduction in recurrence or mortality (HR, 0.66).
• Nonherbal tea and decaffeinated coffee were not associated with patient outcome.
• The association of total coffee intake with improved outcomes seems consistent with other predictors of recurrence and mortality.
Citation: Guercio BJ, Sato K, Niedzwiecki D, et al. Coffee intake, recurrence, and mortality in stage III colon cancer: results from CALGB 89803 (Alliance). [Published online ahead of print August 17, 2015]. J Clin Oncol. doi: 10.1200/JCO.2015.61.5062.