Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Altered Fatty Acid Profiles in Adult Males

Evaluating associations with colon adenomas vs no polyps

Publish date:: January 12, 2016

Plasma phospholipid (PPL) fatty acids (FAs) and enzyme activity estimates (EAEs), which have previously been associated with colorectal cancer (CRC), are significantly different in those with adenomas vs those without polyps. This according to a study of venous blood from 126 males, ages 48 to 65 years, who received routine colonoscopies. Researchers found:

• PPL palmitic acid was inversely correlated with the presence of colon adenomas.

• For each unit increase in palmitoleic acid (OR, 3.75) or elaidic acid (OR, 2.92) an individual was more likely to have adenomas compared to no polyps.

• Higher EAEs of stearoyl-CoA desaturase-1 and elongation of very long chain-6 were associated with about 1.5 times greater likelihood of adenoma compared to no polyps.

Citation: Pickens CA, Lane-Elliot A, Comstock SS, Fenton JI. Altered saturated and monounsaturated plasma phospholipid fatty acid profiles in adult males with colon adenomas. [Published online ahead of print December 31, 2015]. Cancer Epidemiol Biomarkers Prev. doi: 10.1158/1055-9965.EPI-15-0696.

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Mortality risks rise with age, infections, but not inhibitor status in persons with non-severe hemophilia A,

‘Impressive’ local control with MRI-guided brachytherapy in cervical cancer,

U.S. mothers underestimate role breastfeeding plays in curbing breast cancer,

Must Reads in Gastroenterology

Younger adults present with more advanced esophageal adenocarcinoma,

DOACs look safe in elective endoscopic procedures,

Upper GI bleeds in COVID-19 not related to increased mortality,

Cryoballoon, cryospray found equivalent for eradicating Barret’s esophagus,