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Follicular Lymphoma Prevalence in Blacks vs Whites
Ann Hematol; ePub 2016 Oct 12; Colon-Otero, et al
The lower rate of follicular lymphoma (FL) in blacks compared with whites is likely due to differences in secondary molecular alterations involved in its development, according to a study involving 77 individuals.
Investigators isolated DNA from blood samples collected from black (n=77) and white (n=167) participants with FL. After performing polymerase chain reaction, they found that:
- 14% of samples from black patients were positive; 8 were positive for major and 3 for minor breakpoint cluster.
- 15% of the samples from white patients were positive; 22 were positive for major and 5 for minor breakpoint cluster.
- The prevalence of t(14;18)(q32;q21) was not significantly different among blacks and whites.
Citation:
Colon-Otero G, Van Wier S, Ahmann G, et al. Prevalence of bcl-2/j(h) translocation in healthy African Americans. [Published online ahead of print October 12, 2016]. Ann Hematol. doi:10.1007/s00277-016-2842-4.