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Adipokines, Swelling, & Adiposity in HCT Survivors
Biol Blood Marrow Transplant; ePub 2017 Nov 29; Ketterl, et al
Survivors of hematopoietic cell transplantation (HCT) appear to experience unfavorable levels of inflammation, adipokines, and adiposity when compared to siblings with similar BMI, according to a study involving nearly 250 individuals. Participants included HCT survivors (n=151) and siblings (n=92). Investigators looked at inflammatory factors, adipokines, body composition, and adiposity, stratifying by radiation exposure. Among the results:
- Compared with siblings, leptin was significantly higher and adiponectin significantly lower in HCT survivors who received total body irradiation (TBI) with or without central nervous system (CNS) irradiation.
- Interleukin 6 was significantly higher in all groups of HCT survivors, vs siblings.
- BMI was similar between survivors and siblings.
- Percent fat mass was significantly higher in all groups of HCT survivors.
- Lean body mass was lower in survivors who received TBI with and without CNS radiation.
Ketterl T, Chow E, Leisenring W, et al. Adipokines, inflammation, and adiposity in hematopoietic cell transplant survivors. [Published online ahead of print November 29, 2017]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.11.024.