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ALL After Cesarean Delivery

Lancet Hematol. ePub 2016 Feb 26; Marcotte, et al

Publish date:: March 9, 2016

There may be an increased risk of childhood acute lymphoblastic leukemia (ALL) after prelabor cesarean delivery, according to a study of pooled data for which the birth delivery method was known, including 8,655 ALL cases, 1,292 acute myeloid leukemia (AML) cases, and 23,351 controls. Researchers found:

• Odds ratio (OR) for all indications of cesarean delivery and ALL was 1.06, and was significant for prelabor cesarean and ALL (OR=1.23).

• Emergency cesarean delivery was not associated with ALL (OR=1.02).

• AML was not associated with cesarean delivery (all indications OR=0.99; prelabor cesarean delivery OR=0.83; and emergency cesarean delivery OR=1.05).

Citation: Marcotte EL, Thomopoulos TP, Infante-Rivard C, et al. Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC). [Published online ahead of print February 26, 2016]. Lancet Hematol. doi:10.1016/S2352-3026(16)00002-8.

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