Key clinical point: Patients with undifferentiated-predominant mixed-type (MU) early-stage gastric cancer (EGC) had a higher risk for submucosal invasion and lymph node metastasis vs. pure undifferentiated-type (PU) EGC.
Major finding: Patients with MU vs. PU EGC had a significantly higher risk for submucosal invasion (odds ratio [OR] 2.19; 95% CI 1.90-2.52) and lymph node metastasis (OR 2.28; 95% CI 1.72-3.03). There was no difference in the risk for lymphovascular invasion in patients with MU vs. PU EGC (OR 1.81; 95% CI 0.84-3.87).
Study details: This article was a meta-analysis of 12 observational studies including 5644 patients with early gastric cancer.
Disclosures: This study was sponsored by the International Science and Technology Cooperation Fund of Changzhou, China, Young Medical Talents of Jiangsu Province, Changzhou Special Fund for Introducing Foreign Talents, and others. The authors declared no competing interests.
Source: Yang P et al. Undifferentiated-predominant mixed-type early gastric cancer is more aggressive than pure undifferentiated type: a systematic review and meta-analysis. BMJ Open. 2022;12:e054473 (Apr 7). Doi: 10.1136/bmjopen-2021-054473