AML
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Drug for conditioning AML patients for transplant gets orphan drug designation
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Mouse model replicates aggressive AML subtype
Researchers have developed a mouse model of an aggressive type of acute myeloid leukemia (AML) that, they believe, accurately replicates the human...
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Inhibitor exhibits activity against resistant AML
Preclinical research indicates that a novel inhibitor can overcome resistance-conferring FLT3 mutations in acute myeloid leukemia (AML). The...
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Germline mutations linked to hematologic malignancies
A new study suggests mutations in the gene DDX41 occur in families where hematologic malignancies are common. Previous research showed that both...
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Team identifies potential target for aggressive AML
Photo by Rhoda Baer Research published in The Journal of Clinical Investigation has revealed a potential therapeutic target for an aggressive...
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Children’s cancer survival steadily increasing
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Combining inhibitors to treat AML
Preclinical research has revealed a treatment approach that could prove effective against acute myeloid leukemia (AML). Researchers tested the...
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EC grants venetoclax orphan designation for AML
The European Commission has granted orphan drug designation for the oral BCL-2 inhibitor venetoclax to treat acute myeloid leukemia (AML). The EC...
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DNA delivery vehicles may circumvent drug resistance in AML
Image courtesy of PNAS DNA origami nanostructures may be used to overcome drug resistance in acute myeloid leukemia (AML), according to...
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Factors appear to confer poor survival in AML
receiving chemotherapy Photo by Rhoda Baer A study published in the British Journal of Hematology has revealed factors that appear to affect...
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Drug granted breakthrough designation for AML
The US Food and Drug Administration (FDA) has granted breakthrough therapy designation for midostaurin (PKC412) to treat acute myeloid leukemia (...