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Monitoring Progression from Barrett’s Esophagus

Am J Gastroenterol; ePub 2017 Apr 4; Krishnamoorthi, et al

Publish date:: April 27, 2017

Enlisting the assistance of 2 gastrointestinal pathologists can help clinicians monitor the progression of Barrett’s esophagus/low-grade dysplasia (BE/LGD) to high grade dysplasia/esophageal adenocarcinoma (HGD/EAC), suggests an analysis of a multicenter prospective BE registry. The analysis of 244 BE/LGD patients found:

56 patients received the diagnosis of HGD/EAC within 12 months.
14 patients progressed to HGD/EAC after 12 months.
29% of LGD patients were downgraded from LGD to a non-dysplastic state.
The risk of progression to more serious conditions was substantially increased when the researchers brought in an additional panel of 2 expert pathologists to reconfirm LGD diagnoses.

Citation:

Krishnamoorthi R, Lewis JT, Krishna M, et al. Predictors of progression in Barrett’s Esophagus with low-grade dysplasia: Results from a multicenter prospective BE registry. [Published online ahead of print Apr 4, 2017]. Am J Gastroenterol. doi:10.1038/ajg.2017.84.

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