Although vitamin D deficiency often occurs in patients with chronic liver disease, there’s no evidence to suggest vitamin D supplementation has any impact on all-cause mortality, liver-related deaths, health-related quality of life, or adverse events. This according to a recent Cochrane Library review that offered:

• Vitamin D3, vitamin D2, 1,25-dihydroxyvitamin D, and 25-dihydroxyvitamin D supplements did not influence any of the end points described above.
• Since too few trials addressed the question being studied by the Cochrane reviewers, it is still possible that larger, well-designed randomized trials might lead to different conclusions.
• The analysis did not address the impact of vitamin D supplements on the well-documented consequence of vitamin D deficiency, including calcium malabsorption, bone demineralization, secondary hyperparathyroidism, and osteomalacia.