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Disease Activity & Endoscopic Severity in Children with Crohn’s
Gastrointest Endosc; ePub 2018 Sep 28; Carman, et al
In children with newly diagnosed Crohn’s disease (CD), the weighted Pediatric Crohn’s Disease Activity Index (wPCDAI) correlates poorly with endoscopic disease activity. This according to a recent study that compared endoscopic severity with wPCDAI in children aged ≤17 years with newly diagnosed CD. Severity of disease at ileocolonoscopy was assessed by the Simple Endoscopic Score for Crohn’s disease (SES-CD), with segmental subscores noted. Researchers evaluated the association of SES-CD and disease activity markers using the Pearson test of correlation, the Spearman rank coefficient, and linear regression models. The found:
- 280 patients from 11 centers were included in the analysis.
- The median wPCDAI score was 60; median SES-CD was 16.
- The wPCDAI correlated weakly with SES-CD (r = 0.39).
- Examination of the individual components that contribute to the wPCDAI demonstrated weak correlation with SES-CD for all items apart from stooling (moderate correlation, r = 0.50).
- Routine blood tests did not correlate well with SES-CD.
Carman N, Tomalty D, Church PC, et al. Clinical disease activity and endoscopic severity correlate poorly in children newly diagnosed with Crohn’s disease. [Published online ahead of print September 28, 2018]. Gastrointest Endosc. doi:10.1016/j.gie.2018.09.025.