Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Crohn’s Disease Surgeries May Be Declining

Am J Gastroenterol; 2017 Dec; Ma, et al

Publish date:: January 4, 2018

Fewer surgeries are being done to manage Crohn’s disease, suggests a recent Canadian study, but there’s been a shift from emergent to elective operations over the years.

A population-based analysis that looked at ICD-10 codes for surgical resections from fiscal years 2002 to 2012 identified 981 adults who had the procedure done to treat Crohn’s disease.
In this time frame, the overall surgical resection rate was 3.8 per 100 persons-years.
The overall surgical rate decreased by 3.5% per year as a result of a drop in emergency procedures, which declined by 10.1% per year.
Elective surgeries, on the other hand, increased by 3.7% per year.

Citation:

Ma C, Moran GW, Benchimol EI, et al. Surgical rates for Crohn’s Disease are decreasing: A population-based time trend analysis and validation study. Am J Gastroenterol. 2017;112:1840-1848. doi:10.1038/ajg.2017.394.

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Endoscopic intragastric balloon improved NASH parameters,

Autologous fecal microbiota transplantation helped maintain weight loss after ‘green’ Mediterranean diet,

Cryoballoon, cryospray found equivalent for eradicating Barret’s esophagus,

Must Reads in IBD & Intestinal Disorders

Normal gut colonizer induces serotonergic system, appears to regulate behavior,

IL-23 plays key roles in antimicrobial macrophage activity,

Diarrhea prevalent among COVID-19 patients with IBD,

Complete endoscopic healing tied to better Crohn’s disease outcomes,

Studies eyes risks for poor outcomes in primary sclerosing cholangitis,