135 patients at high-risk for pancreatic cancer must be screened to identify 1 patient with a high-risk pancreatic lesion, based on findings from a recent meta-analysis that sought to determine the diagnostic yield and outcomes of abdominal imaging screening for asymptomatic individuals at high risk. The primary outcome was identification of high-risk pancreatic lesions at initial screening and overall incidence at follow-up. Among the details:

• 19 studies comprising 7,085 individuals at high risk for pancreatic cancer were included; of these, 1,660 were evaluated by endoscopic ultrasound (EUS) and/or MRI.
• 59 high-risk lesions were identified and 257 patients underwent pancreatic surgery.
• The overall diagnostic yield screening for high-risk pancreatic lesions was 0.74 with moderate heterogeneity among studies.
• The number needed to screen to identify 1 patient with a high-risk lesion was 135.