Key clinical point: The use of antibiotics and acid-suppressants during the prenatal period and infancy increased the risk of developing eosinophilic esophagitis (EoE) later in life.
Major finding: The risk for EoE increased by 50% in offsprings who were administered antibiotics during the prenatal period ( adjusted odds ratio [aOR] 1.5; 95% CI 1.2-1.9 ); moreover, the administration of antibiotics ( aOR 1.4; 95% CI 1.1-1.7 ) and acid-suppressants ( aOR 15.9; 95% CI 9.1-27.7 ) in infancy was significantly associated with an increased risk for EoE.
Study details: Findings are from a case-control study including 392 children with EoE and 3637 age- and sex-matched control individuals without EoE.
Disclosures: This study was supported by a grant from the US National Institutes of Allergy and Infectious Diseases. Some authors declared receiving grants, consulting fees, or funding from various sources.
Source: Jensen ET et al. Maternal and infant antibiotic and acid suppressant use and risk of eosinophilic esophagitis. JAMA Pediatr. 2023;177(12):1285-1293 (Oct 30). doi: 10.1001/jamapediatrics.2023.4609
