The 8 risk variables used in 3 scoring systems have predictive value in patients with either post-polycythemia vera (post-PV MF) or post-essential thrombocythemia myelofibrosis (post-ET MF), according to a study involving 125 individuals. Participants had primary MF (PMF), prefibrotic PMF, post-ET MF, or post-PV MF. Investigators looked at whether the 8 variables used in the International Prognostic Scoring System (IPSS), dynamic IPSS (DIPSS), and DIPSS-plus could predict shortened survival in post-PV/ET MF. Among the results:

• At a median follow-up of 3 years after fibrotic progression began, nearly 70% died.
• 5 risk variables used in IPSS or DIPSS predicted shortened survival for all but constitutional symptoms.
• Patients with circulating blasts ≥1%, were more than twice as likely to experience shortened survival.
• Those with hemoglobin 25 x 10⁹/L were nearly twice as likely to experience such.
• The 8 risk variables used in DIPSS-plus predicted all except constitutional symptoms and leukocyte count >25 x 10⁹/L with borderline significance.