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Differential Tissue Expression of Proteins in PC
Key clinical point: A new candidate for prostate cancer (PCa) markers was identified from proteomic profiling of extracellular vesicles from prostate cancer and normal prostate cell lines.
Major finding: Nuclear exportin protein XPO1 was higher in PCa compared to normal adjacent prostate in the data analysis.
Study details: Protein fractions from 67 tissue samples were analyzed by mass spectrometry.
Citation:
Duijvesz D, et al. Prostate. 2019 Apr 24. doi: 10.1002/pros.23813.
Much research has gone into identifying biomarkers that are easily obtainable (such as from blood) and may be clinically useful for early detection, prognostic value, and/or are predictive for response to particular therapeutic modalities. In this study, Duijvesz evaluated whether some key proteins identified from exosomes may have diagnostic and prognostic value in prostate cancer. Exosomes are secreted from cells and contain distinct protein and mRNA profiles. In this study, no significant correlations between a small and select group of proteins from exosomes and clinical outcomes were identified. However, this was a small group and further study is certainly warranted. —Mark A. Klein, MD